Laboratory of 
Analytical Chemistry and Biopolymer Structure Analysis

 

Mihaela Stumbaum
PhD-student
Laboratory for Analytical Chemistry
Department of Chemistry
University of Konstanz

78457 Konstanz

 

Room R 803
Ph.:
 +49 7531 88-3391
Fax:
+49 7531 88-3391
E-mail: Mihaela.Dragusanu@Uni-konstanz.de

Curriculum vitae

27.12.1979

born in Barlad, Romania.

 

1987-1995

Primary School in Vaslui, Romania.

 

1995-1999

High School “Mihail Kogalniceanu” in Vaslui, Romania.

 

1999-2001

2 years of Chemistry studies at the University Al. I. Cuza Iasi, Romania.

 

2001-2006

Studies of Chemistry and Diploma thesis at the University Konstanz, Germany.
Thesis: "Synthesis and characterization of tyrosine nitrated peptides by affinity-mass spectrometry using anti-3-nitrotyrosine antibodies”.

 

2001-2006

Scholarship from Herbert Quant-Foundation at the University Konstanz, Germany.

 

3-6 October 2006

Poster presentation at the "Oxidative Post-Translational Modifications of Proteins in Cardiovascular Disease" Symposium in Boston, USA.
Title: “Epitope identification of 3-nitrotyrosine peptides by monoclonal anti-3-nitrotyrosine antibodies using proteolytic epitope excision mass spectrometry method”.

 

Januar 2007-to date

PhD studies at the Laboratory of Analytical Chemistry, Department of Chemistry, University of Konstanz, Germany.
PhD thesis: “Development and Bioanalytical application of affinity-mass spectrometric methods for investigation of structural modifications in proteins”.

 

Research area

The goal of the PhD thesis is to investigate the oxidative modifications in proteins by affinity-mass spectrometry methods and to identify the epitope of the prostacyclin synthase using anti-3-nitrotyrosine antibody. One of the oxidative modifications is the tyrosine nitration. The oxidative modification in proteins by nitration may occur at very low stoechiometric levels, hence affinity- mass spectrometry should be the most efficient method for identification.