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Published in Environment International, a groundbreaking study from the Institute of Biological Chemistry and Centre for Microbiology and Environmental Systems Science (CeMESS) at the University of Vienna, in collaboration with the University of Konstanz and the Albert Einstein College of Medicine, reveals a microbial metabolite's role in inducing Parkinson's-like symptoms. This discovery could reshape our understanding of the environmental triggers of Parkinson's disease.

The underlying causes of Parkinson's disease, a debilitating neurodegenerative condition, are not well understood. While genetic mutations are known to cause Parkinson's, a staggering 90% of cases are sporadic, with no clear genetic origin. Scientists suspect environmental factors could play a role – and substances like pesticides and industrial chemicals have been investigated for potential links to neurodegeneration. Among the possible culprits also are microbial metabolites.

Recent studies highlight the gut-brain axis's importance, suggesting that our gut bacteria (microbiome) might influence neurodegenerative diseases. Notably, the gut microbiome of Parkinson's patients differs from that of healthy individuals. Some toxins produced by gut bacteria (microbial metabolites) have been shown to target dopamine-producing nerve cells in the brain. This may explain the loss of these neurons in Parkinson's disease.

Motivated by these findings and the potential role of a specific bacterial metabolite in inducing Parkinson's-like symptoms, researchers from the University of Vienna, the University of Konstanz, and the Albert Einstein College of Medicine embarked on a comprehensive study. They focused on a metabolite produced by the bacterium Streptomyces venezuelae, which previous research hinted might cause selective damage to dopamine-producing neurons.

The team isolated and identified this metabolite and exposed human dopamine-producing neurons to it. The results were clear: the metabolite had a destructive effect, mirroring the neuronal loss observed in Parkinson's disease. To further validate their findings, the researchers introduced this bacterial metabolite to worms, which then exhibited movement difficulties and specific neuronal patterns akin to those seen in human Parkinson's patients.

Marcel Leist from the University of Konstanz and Thomas Böttcher from the University of Vienna collaborated in spearheading this pioneering study that bridges the realms of microbial biochemistry and molecular neuroscience. The scientists remarked, "Our research provides a tangible link between a specific bacterial metabolite and symptoms resembling Parkinson's disease. It's a step forward in understanding how our environment, down to the microbes around us, might influence the onset or progression of such diseases."

This discovery not only offers a fresh perspective on the triggers of Parkinson's but also opens up new avenues for research. Could other microbial substances influence neurodegenerative diseases? How do these substances interact with our neurons? And most importantly, can this knowledge lead to new treatments or preventive measures? While the study is just the beginning, it's a promising step towards unraveling the mysteries of Parkinson's and other neurodegenerative diseases.

Key facts:

• Original publication:
  Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration Anna-Katharina Ückert, Sina Rütschlin, Simon Gutbier, Nathalie Christine Wörz, Mahfuzur R. Miah, Airton C. Martins, Isa Hauer, Anna-Katharina Holzer, Birthe Meyburg, Ann-Kathrin Mix, Christof Hauck, Michael Aschner, Thomas Böttcher, Marcel Leist
  Environment International, Volume 180, 2023, 108229
  https://doi.org/10.1016/j.envint.2023.108229.
  https://www.sciencedirect.com/science/article/pii/S0160412023005020
• Microbial metabolite that destroys dopamine-producing neurons discovered by a team led by Marcel Leist from the University and Thomas Böttcher from the Institute of Biological Chemistry and Centre for Microbiology and Environmental Systems Science (CeMESS) at the University of Vienna, in collaboration with the Albert Einstein College of Medicine
• The destructive effect of the metabolite from the bacterium Streptomyces venezuelae led to a loss of neurons similar to that seen in Parkinson's disease
• Funding by the German Research Foundation (DFG) in the context of the German Excellence Strategy and by the state of Baden-Württemberg to support 3R research