![Ribosome binding of NAC is mediated by a ribosome binding regulatory arm (N-αNAC, blue) and a translation sensor domain (N-βNAC, green). N-βNAC senses short nascent chains already deep inside the ribosomal tunnel close to the peptidyl-transferase centr Ribosome binding of NAC is mediated by a ribosome binding regulatory arm (N-αNAC, blue) and a translation sensor domain (N-βNAC, green). N-βNAC senses short nascent chains already deep inside the ribosomal tunnel close to the peptidyl-transferase centre (orange) where amino acids are assembled into proteins. The tunnel-sensing activity of NAC is believed to orchestrate general cotranslational protein folding and transport processes in the cell. Copyright: Martin Gamerdinger](/fileadmin/_processed_/3/d/csm_new_protein-sensing_th_a2605d9185.jpg)
New protein-sensing mechanism discovered
In a stunning discovery, molecular biologists from the University of Konstanz and ETH Zurich have been able to demonstrate that the nascent polypeptide-associated complex (NAC) senses newly synthesized proteins upon birth inside the ribosomal tunnel
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